Growth of pseudotypes of vesicular stomatitis virus with N-tropic murine leukemia virus coats in cells resistant to N-tropic viruses.

نویسندگان

  • A S Huang
  • P Besmer
  • L Chu
  • D Baltimore
چکیده

Formation of pseudotypes between murine RNA tumor viruses and vesicular stomatitis virus (VSV) has been confirmed. Pseudotypes of VSV genomes coated by the surface envelope from an N-tropic tumor virus grew equally well in cells homozygous for either the Fv-1(n) or Fv-1(b) alleles. Therefore, the product of the Fv-1 locus, which restricts growth of murine RNA tumor viruses, must act on an intracellular aspect of tumor virus replication, a step after attachment and penetration.

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عنوان ژورنال:
  • Journal of virology

دوره 12 3  شماره 

صفحات  -

تاریخ انتشار 1973